Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

BY Sui and ZY Xu and ZY Xue and Y Xiang and T Zhou and AM Beltrán and K Zheng and X Liu and AR Boccaccini, ACS APPLIED MATERIALS & INTERFACES, 15, 29550-29560 (2023).

DOI: 10.1021/acsami.3c03680

Exploring new approaches to realize the possibility ofincorporatingbiologically active elements into mesoporous silicate bioactive glassnanoparticles (MBG NPs) and guaranteeing their meso- structural integrityand dimensional stability has become an attractive and interestingchallenge in biomaterials science. We present a postgrafting strategyfor introducing different metal elements into MBG NPs. This strategyis mediated by polydopamine (PDA) coating, achieving uniform loadingof copper or copper-cobalt on the particles efficiently andensuring the stability of MBG NPs in terms of particle size, mesoporousstructure, and chemical structure. However, the PDA coating reducedthe ion-binding free energy of the MBG NPs for calcium and phosphateions, resulting in the deposition of minimal CaP clusters on the PDA@MBGNP surface when immersed for 7 days in simulated body fluid, indicatingthe absence of hydroxyapatite mineralization.

Return to Publications page